Dynemicin A is a member of the family of enediyne natural the enediyne, and the oxirane ring but lack the nitrogen heterocycle. In these compounds the aryl ring assumes a products. It is unique in that it combines a ten-membered enediyne with an anthraquinone substructure. These different conformation from that in dynemicin A. Many of the simplified analogs proved to be quite active in vitro as well features stimulated the development of synthetic approaches to the natural product itself and of analogs thereof. This in vivo against murine tumor models. A highlight is compound 30 which is much more active than dynemicin A review summarizes the total syntheses of dynemicin A. In addition, an overview of the known analogs is presented.
itself. However, looking at all analogs there is no clear-cut correlation between the DNA-cleaving ability at neutral pH The analogs can be classified according to the designed trigger mechanism. Most of the analogs contain a removable and the in vitro results. From this one might conclude that there are possibly two mechanisms for antitumor activity. carbamate on the nitrogen atom. Others are quite similar to the natural lead in that they contain a quinone substructure, One involves diradical formation whereas the other might be due to a ligand-receptor interaction. which upon reduction causes opening of the oxirane ring. In addition, there are analogs that contain an aromatic sector, ing agents. In the case of the mitosenes, two-electron re-