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Design and Synthesis of Dipeptidyl Glutaminyl Fluoromethyl Ketones as Potent Severe Acute Respiratory Syndrome Coronovirus (SARS-CoV) Inhibitors

✍ Scribed by Zhang, Han-Zhong; Zhang, Hong; Kemnitzer, William; Tseng, Ben; Cinatl,, Jindrich; Michaelis, Martin; Doerr, Hans Wilhelm; Cai, Sui Xiong


Book ID
126087112
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
59 KB
Volume
49
Category
Article
ISSN
0022-2623

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## Abstract Severe acute respiratory coronavirus (SARS‐CoV) spike (S) glycoprotein fusion core consists of a six‐helix bundle with the three C‐terminal heptad repeat (HR2) helices packed against a central coiled‐coil of the other three N‐terminal heptad repeat (HR1) helices. Each of the three perip