Synthesis of Novel Isoxazolinyl Substituted Imidazo[1,2-a]pyridine C-Nucleoside Analogues. -The title isomeric C-nucleoside analogues (VI) and (IX) having hydroxymethyl-substituted isoxazoline rings in place of the ribose ring are prepared by a strategy involving cycloaddition of olefins to interme
Design and Synthesis of Acyclic Nucleoside Analogues with Chlorinated Imidazo[1,2-a]pyridine Bases.
β Scribed by John D. Williams; Alaa E. Mourad; John C. Drach; Leroy B. Townsend
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 90 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Benzofuroylhydroxamoyl chloride (3) reacted with acrylonitrile, N-tolylmaleimide and active methylene compounds to afford the isoxazoline 4, the pyrrolidino13,4-d]isozazoline 5 and the isoxazole derivatives 6, 7, respectively. Nitrosoirnidazo[ 1,2-alpyridines 10 and the imidazo[ 1,2-alpyrimidine 12