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Design and Synthesis of a Tetracyclic Pyrimidine-Fused Benzodiazepine Library.

โœ Scribed by Lianyou Zheng; Jinbao Xiang; Qun Dang; Sigen Guo; Xu Bai


Publisher
John Wiley and Sons
Year
2006
Weight
35 KB
Volume
37
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Abstract

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## Abstract Benzodiazepines 3aโ€“d have been synthesized by the reaction of exocyclic ฮฑ,ฮฒโ€unsaturated ketones 1aโ€“d with 1,2โ€phenylenediamine in hot ethanol. Acetylation of compounds 3aโ€“d with a mixture of acetic anhydride and anhydrous pyridine affords the __N__โ€acetyl derivatives 4aโ€“d. Structure and