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Design and synthesis of a novel intercalating isoxazolyl bis-lexitropsin conjugate

✍ Scribed by Xiaochun Han; Nicholas R. Natale

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
55 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

9‐Anthracene nitrile oxide directly generated from 9‐anthracenealdoxime and N‐chlorosuccinamide (NCS), reacts with dimethyl acetylenedicarboxylate (DMAD) and affords the corresponding 3‐(9′‐anthra‐cenyl)‐isoxazole‐4,5‐dicarboxylic acid ester (3) with good yield in a very short period. Double activation reaction between (3) and hydrogenated lexitropsin (5) in a 1:2 molar ratio, produced a bis‐lexitropsin product (6) (major product) and mono‐lexitropsin product (7).

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