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Design and Synthesis of a Monofluoro-Substituted Aromatic Amino Acid as a Conformationally Restricted 19 F NMR ­Label for Membrane-Bound Peptides

✍ Scribed by Tkachenko, Anton N.; Mykhailiuk, Pavel K.; Radchenko, Dmytro S.; Babii, Oleg; Afonin, Sergii; Ulrich, Anne S.; Komarov, Igor V.


Book ID
124089169
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
551 KB
Volume
2014
Category
Article
ISSN
1434-193X

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## Abstract The conformation, alignment and dynamic behavior of membrane‐bound peptides is readily accessible by solid‐state ^19^F‐NMR spectroscopy, but it has been difficult to incorporate suitable ^19^F‐labelled amino acids into synthetic peptides. To avoid the drawbacks of previously used labels