Design and synthesis of a hapten for the radioimmunoassay of bupropion

✍ Scribed by Nariman B. Mehta; David L. Musso

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 302 KB
• Volume: 75
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600750420

✦ Synopsis

The synthesis of a hapten useful in the radioimmunoassay of bupropion is described. Since bupropion has no functional group that can be easily derivatized, a hydroxypropyl group was incorporated into the molecule. Studies in cross-reactivity with possible metabolites required the synthesis of the 4'-hydroxy analogue of bupropion. This synthesis is also described.