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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole-5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model.

✍ Scribed by Balasubramanian, Balu N.; St. Laurent, Denis R.; Saulnier, Mark G.; Long, Byron H.; Bachand, Carol; Beaulieu, Francis; Clarke, Wendy; Deshpande, Milind; Eummer, Jeffrey; Fairchild, Craig R.; Frennesson, David B.; Kramer, Robert; Lee, Frank Y.; Mahler, Mikael; Martel, Alain; Naidu, B. Narasimhulu; Rose, William C.; Russell, John; Ruediger, Edward; Solomon, Carola; Stoffan, Karen M.; Wong, Henry; Wright, John J.; Zimmermann, Kurt; Vyas, Dolatrai M.

Book ID
127165799
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
28 KB
Volume
48
Category
Article
ISSN
0022-2623

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Design and Synthesis of a Fluoroindoloca
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]- thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole- 5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model §
✍ Balasubramanian, Balu N.; St. Laurent, Denis R.; Saulnier, Mark G.; Long, Byron 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 96 KB