Design and Synthesis of a Conformationally Restricted Cysteine Protease Inhibitor
β Scribed by Cheng, Hengmiao; Keitz, Paul; Jones, J. Bryan
- Book ID
- 111688235
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 760 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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The use of conformationally restricted phospholipids 1 and 2 has been employed to understand the conformational preference of phospholipase A2 (PLA2) for substrate phospholipids. Inhibition of porcine pancreatic PLA2 with 1 and 2 indicated a two-to fivefold preference for the distal isomer 2 over th