Design and Synthesis of 4-Substituted Indolo[3,2- e ][1,2,3]triazolo[1,5- a ]pyrimidine Derivatives with Antitumor Activity
β Scribed by Lauria, Antonino; Patella, Chiara; Dattolo, Gaetano; Almerico, Anna Maria
- Book ID
- 127153888
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 375 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-2623
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Synthesis of New 2-Substituted-pyrazolo[4',3':5,6]pyrano[3,2e][1,2,4]triazolo [1,5-c]pyrimidine Derivatives. -Starting from pyrazole (III) the pyrimidine (V) is prepared which is further treated with different carboxylic acid derivatives to form novel pyrimidines of type (VI) and (VIII). Preparatio
## Abstract A series of pyrazolo[4,3β__e__]β1,2,4βtriazoloβ[1,5β__c__]pyrimidine derivatives, bearing phosphonylbenzyl chain in position 7, were conveniently synthesized in an attempt to obtain potent and selective antagonists for the A~2__A__~ adenosine receptor or potent pesticide lead compounds.