✦ LIBER ✦

Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands

✍ Scribed by Guiying Li; Hao Zhou; Yu Jiang; Holger Keim; Sidney W. Topiol; Suresh B. Poda; Yong Ren; Gamini Chandrasena; Darío Doller

Book ID: 104005244
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 561 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.12.068

No coin nor oath required. For personal study only.

✦ Synopsis

Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT(1) and MT(2) receptors are reported. Compounds 11f and 18b (MT(1)/MT(2) agonist) have human microsomal intrinsic clearance comparable to ramelteon.

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