Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-κB inhibitors
✍ Scribed by Choi, Minho; Hwang, Young-Sik; Kumar, Arepalli Sateesh; Jo, Hyeju; Jeong, Yeongeun; Oh, Yunju; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Heesoon
- Book ID
- 121731250
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 334 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0960-894X
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## Abstract Two new structurally isomeric, 2‐(2,4,4‐trimethyl‐3,4‐dihydro‐2__H__‐benzo[__h__]chromen‐2‐yl)‐1‐naphthol (**1****)** and 3‐(2,4,4‐trimethyl‐3,4‐dihydro‐2__H__‐benzo[__g__]chromen‐2‐yl)‐2‐naphthol (**3**) have been synthesized from 2‐acetyl‐1‐naphthol and ethyl‐3‐hydroxy‐2‐naphthoate, r
Novel 2H-benzo[b][1,4]oxazin-3(4H)-ones have been synthesized by condensation, reduction, O-alkylation and Smiles rearrangement using 3-bromo-4-hydroxy benzaldehyde, anilines, and chloroacetyl chloride as starting materials. All the synthesized compounds have been characterized by (1)H NMR, (13)C NM