Replacements for lysine in l-seryl-l-lys
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David L. Brown; Balekudru Devadas; Hwang-Fun Lu; Srinivasan Nagarajan; Mark E. Z
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Article
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1997
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Elsevier Science
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English
β 225 KB
A survey of potential cyclic and acyclic lysine replacements in known L-seryl-L-lysyl dipeptide inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as submicromolar inhibitors of C. albicans NMT, which retained good selectivity over the human enzyme. All of the heterocyclic