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Design and Syntheses of Potent and Selective Dipeptide Inhibitors of Candida albicans Myristoyl-CoA:Protein N-Myristoyltransferase

✍ Scribed by Devadas, Balekudru; Zupec, Mark E.; Freeman, Sandra K.; Brown, David L.; Nagarajan, Srinivasan; Sikorski, James A.; McWherter, Charles A.; Getman, Daniel P.; Gordon, Jeffrey I.


Book ID
126310119
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
437 KB
Volume
38
Category
Article
ISSN
0022-2623

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Replacements for lysine in l-seryl-l-lys
✍ David L. Brown; Balekudru Devadas; Hwang-Fun Lu; Srinivasan Nagarajan; Mark E. Z πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 225 KB

A survey of potential cyclic and acyclic lysine replacements in known L-seryl-L-lysyl dipeptide inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as submicromolar inhibitors of C. albicans NMT, which retained good selectivity over the human enzyme. All of the heterocyclic