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Design and Scale-Up of a Practical Enantioselective Route to 5-Phenylbicyclo[2.2.2]oct-5-en-2-one

✍ Scribed by Abele, Stefan; Inauen, Roman; Funel, Jacques-Alexis; Weller, Thomas


Book ID
111971738
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
883 KB
Volume
16
Category
Article
ISSN
1083-6160

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High enantioselectivity was achieved in the lipase-catalyzed kinetic resolution of 5-hydroxypyrrolidin-2one and 5-hydroxy-1,5-dihydropyrrol-2-one derivatives. Lipase PS and Novozym 435 were the successful catalysts (E=>1000). The acetylation of the N-protected 5-hydroxy-1,5-dihydropyrrol-2-one deriv