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Design and optimization of a linker for fusion protein construction

โœ Scribed by Jianhua Zhang; Jun Yun; Zhigang Shang; Xiaohui Zhang; Borong Pan

Book ID
113855947
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
104 KB
Volume
19
Category
Article
ISSN
1002-0071

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Computational methods play a central role in the rational design of novel proteins. The present work describes a new hybrid exact rotamer optimization (HERO) method that builds on previous dead-end elimination algorithms to yield dramatic performance enhancements. Measured on experimentally validate