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Design and gene delivery activity of modified polyethylenimines

✍ Scribed by Ralf Kircheis; Lionel Wightman; Ernst Wagner

Book ID
114176000
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
636 KB
Volume
53
Category
Article
ISSN
0169-409X

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Background Linear polyethylenimine (LPEI) with a molecular weight (MW) of 22 kDa has been described as having a superior ability to induce gene transfer compared to its branched form. However, the transfection efficiency of the polymer cannot be enhanced beyond a certain limit due to cytotoxicity. W