Design and evaluation of oral bioadhesive controlled release formulations of miglitol, intended for prolonged inhibition of intestinal α-glucosidases and enhancement of plasma glucagon like peptide-1 levels

Prolonged and enhanced secretion of gluc

Prolonged and enhanced secretion of glucagon-like peptide 1 (7-36 amide) after oral sucrose due to α-glucosidase inhibition (acarbose) in Type 2 diabetic patients

✍ Seifarth, C.; Bergmann, J.; Holst, J.J.; Ritzel, R.; Schmiegel, W.; Nauck, M.A. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB 👁 1 views

GLP-1, an incretin hormone of the enteroinsular axis with insulinotropic and glucagonostatic activity, is secreted after nutrient ingestion. GLP-1 is mainly produced by intestinal L-cells in the lower gastrointestinal tract (GIT); simple carbohydrates are absorbed in the upper GIT and ␣-glucosidase