Design and evaluation of layered diffusional matrices for zero-order sustained-release
โ Scribed by Yihong Qiu; N Chidambaram; Kolette Flood
- Book ID
- 114163341
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 309 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0168-3659
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## Abstract Implantable, sustained release drug delivery devices offer benefits not obtained through oral ingestion or injection. These include delivery at a constant therapeutic rate, thus avoiding adverse intermittent and massive dose effects, as well as reliance upon patients taking their prescr
The potential advantages and disadvantages of incorporating an immediate-release (IR) component in sustained-release formulations with zero-order release characteristics (SR) are discussed. The dose of the IR component for SR doses other than the first one (DIS) should be less than that for the firs