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Design and development of analogues of dimers of insulin-like peptide 3 B-chain as high-affinity antagonists of the RXFP2 receptor

✍ Scribed by Fazel Shabanpoor; Suode Zhang; Richard A. Hughes; Mohammed Akhter Hossain; Sharon Layfield; Tania Ferraro; Ross A. D. Bathgate; Frances Separovic; John D. Wade

Publisher: Wiley (John Wiley & Sons)
Year: 2011
Tongue: English
Weight: 544 KB
Volume: 96
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.21484

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## Abstract Insulin‐like peptide 3 (INSL3) is a peptide hormone belonging to the relaxin‐insulin superfamily of peptides that plays important roles in testes descent, oocyte maturation and the control of male germ cell apoptosis. These actions are mediated via a specific G‐protein coupled receptor,