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Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets

✍ Scribed by Baurin, N.; Aboul-Ela, F.; Barril, X.; Davis, B.; Drysdale, M.; Dymock, B.; Finch, H.; Fromont, C.; Richardson, C.; Simmonite, H.; Hubbard, R.E.


Book ID
121267281
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
169 KB
Volume
44
Category
Article
ISSN
0095-2338

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✍ Anna Vulpetti; Nikolaus Schiering; Claudio Dalvit πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 800 KB

## Abstract ^19^F NMR screening of fluorinated fragments with different Local Environment of Fluorine, a.k.a. LEF library, is an experimental methodology which, beyond providing useful starting fragments for fragment‐based drug discovery projects, offers, in combination with crystal and computation