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Design and Analysis of Group Sequential Tests Based on the Type I Error Spending Rate Function

✍ Scribed by Kyungmann Kim and David L. DeMets


Book ID
124289323
Publisher
Oxford University Press
Year
1987
Tongue
English
Weight
651 KB
Volume
74
Category
Article
ISSN
0006-3444

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## Abstract Because most multipoint linkage analysis programs currently assume linkage equilibrium between markers when inferring parental haplotypes, ignoring linkage disequilibrium (LD) may inflate the Type I error rate. We investigated the effect of LD on the Type I error rate and power of nonpa