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Design and Analysis of Group Sequential Clinical Trials with Multiple Primary Endpoints

โœ Scribed by Michael R. Kosorok; Shi Yuanjun; David L. DeMets

Book ID
110725142
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
220 KB
Volume
60
Category
Article
ISSN
0006-341X

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We consider multivariate tests for comparing two treatments with multiple endpoints. The test decision is drawn from the simultaneous consideration of the univariate tests for the single endpoints. A general class of these tests, called cut-o! tests, can be given, which, however, can lead to highly