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Desensitization to Temozolomide

✍ Scribed by Mhanna, H.; Jiménez Blanco, A.; Valdez Tejeda, M.; Jukic Beteta, K.; Sánchez González, M.; Fernandez Rodriguez, C.; Vives Conesa, R.

Book ID: 119284945
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 39 KB
Volume: 127
Category: Article
ISSN: 1097-6825
DOI: 10.1016/j.jaci.2010.12.783

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## Abstract ## BACKGROUND Temozolomide (TMZ) often is used as adjuvant or first‐line therapy for patients with glioma. Because of potential hematologic complications, it usually is discontinued after 12–18 cycles, even in responders. Subsequent salvage therapies are reported to have limited effica