Desensitization of soluble guanylyl cyclase, the NO-receptor, by S-nitrosylation
β Scribed by Nazish Sayed; Padmamalini Baskaran; Focco van den Akker; Annie Beuve
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 183 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2210
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The heat-stable enterotoxins (ST) are a family of cysteine-rich low-molecular weight peptides produced by pathogenic bacteria, and are one of the major causes of watery diarrhea all over the world. These toxins mediate their action by binding to an intestinal cell surface receptor that is a membrane
The heat-stable enterotoxin STa of E. coli causes diarrhea by binding to and stimulating intestinal membrane-bound guanylyl cyclase, triggering production of cyclic GMP. Agents which stimulate protein kinase C (PKC), including phorbol esters, synergistically enhance STa effects on cGMP and secretion