## Abstract To investigate the possible causal association between squamousโcell carcinomas of the oral cavity and use of toombak, we retrospectively compared the history of use of this substance in 375 patients with squamousโcell carcinomas of the lip, buccal cavity and floor of mouth, and 271 pat
Descriptive epidemiology of oral neoplasms in sudan 1970-1985 and the role of toombak
โ Scribed by A. M. Idris; H. M. Ahmed; B. I. Mukhtar; A. F. Gadir; E. I. El-Beshir
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 465 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0020-7136
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โฆ Synopsis
Data from 1,916 cases of oral neoplasms occurring in the Sudan in a 16-year period, from January 1970 to December 1985, were retrieved and analysed. The study revealed a relatively high frequency of oral neoplasms in comparison with neighbouring countries. In this study, squamous-cell carcinoma was the most common oral malignancy (66.5%), followed by tumours of the salivary gland (14.7%), neoplasms of nonodontogenic and non-epithelial origin (9.6Yo) and odontogenic neoplasms (8.6%). Men had a higher frequency than women. The older age group of both genders showed a relatively high frequency of squamous-cell carcinoma. Among northern Sudanese there was a high rate of scpamous-cell carcinoma, while southern Sudanese showed a high rate of odontogenic and salivary-gland neoplasms. The use of toombak has been stated to play a major role in the aetiology of oral squamous-cell carcinoma in the Sudan, and is suspected to be associated with neoplasms of the salivary glands.
๐ SIMILAR VOLUMES
Using PCR-SSCP/DNA sequencing methods, we analyzed 14 oral squamous-cell carcinomas (OSCCs) and 8 premalignant oral lesions from different Sudanese patients for prevalence of mutations in exons 5 to 9 of the p53 gene in relation to toombak-dipping status. OSCCs (14 from Sudan, 28 from Scandinavia),