✦ LIBER ✦
Descladinosyl erythromycin in phosgene-assisted cyclic 3,6-ether formation
✍ Scribed by Audun Heggelund; Kjell Undheim
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 222 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
- Reagents and conditions for cyclic ether formation: (i) HCl, EtOH/H 2 O (2:1), rt, 100 min; (ii) (a) COCl 2 , pyridine, CH 2 Cl 2 , rt, 22 h, (b) MeOH, 30 min. Scheme 2. Reagents and conditions: (i) COCl 2 , pyridine, CH 2 Cl 2 , rt, 5 h; (ii) CH 2 @CHCH 2 OH, rt, 30 min. Scheme 3. Reagents and conditions for deprotection: (i) Pd(OAc) 2 , PPh 3 , HCO 2 H/NEt 3 , EtOH, H 2 O, reflux, 55 min; (ii) DMP, wet CH 2 Cl 2 , rt, 30 min.