Desacetylalacepril, a metabolite of alacepril, prevents oxidation of LDL and inhibits cholesteryl ester accumulation in mouse peritoneal macrophages

Eicosapentaenoic acid inhibits cholester

Eicosapentaenoic acid inhibits cholesteryl ester accumulation in rat peritoneal macrophages by decreasing the number of specific binding sites of acetyl LDL

✍ Ichiro Saito; Hiroyuki Saito; Yasushi Tamura; Sho Yoshida 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 512 KB

We found that rat peritoneal macrophages bind acetyl low density lipoprotein (AcLDL) by a saturable and specific manner and accumulate a substantial amount of cholesteryl ester (CE) when incubated with AcLDL. In macrophages enriched with eicosapentaenoic acid (EPA) by the ingestion of highly purifie