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Derivatives of α-tetronic acid

✍ Scribed by A.G. Long; A.F. Turner

Publisher
Elsevier Science
Year
1963
Tongue
French
Weight
272 KB
Volume
4
Category
Article
ISSN
0040-4039

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✦ Synopsis

ABRAHAM and NEWTON1 obtained the lactone (I) from cephalosporin C. We have studied simpler lactones of this type. We made our compounds from the Mannich bases derived from pyruvic acid, formaldehyde and certain secondary amines: 2 for instance, piperidine sulphate gave the a-tetronic acid derivative (III), from which the free base (IV) was obtained by treatment with barium hydroxide.

We expected such Mannich bases to undergo substitution of the type advanced here to account for formation of the methylene derivative (V), CgHS06, a by-product* (the "C15Hl,+010-Acid") in the preparation of the hydrochloride (II).

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