✦ LIBER ✦

Derivatives of natural tetrapyrroles for photodynamic therapy, 3. Oxidative degradation studies on porphyrins with chromic acid

✍ Scribed by Gauler, Rainer ;Hesse, Ulrike ;Risch, Nikolaus

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 390 KB
Volume: 1995
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.1995199512309

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Until now the composition of the complex porphyrin mixtures of hematoporphyrin derivative (HPD) and Photofrin II could not be clarified in detail. We investigated the applicability of oxidative degradation to the structural assignment of HPD constituents. Therefore, some fundamental work concerning the characterization of the relevant degradation products had to be done. In this article we present the spectral and analytical data of monomeric and dimeric maleimides potentially arising from the corresponding constituents of HPD.

📜 SIMILAR VOLUMES

Derivatives of Natural Tetrapyrroles for

Derivatives of Natural Tetrapyrroles for Photodynamic Therapy, 4. Oxidative Degradation Studies: Direct Analysis and Determination of Ether and Ester Linkages in Porphyrin Dimers and Oligomers of Hematoporphyrin Derivative (HPD),

✍ Risch, Nikolaus ;Hesse, Ulrike ;Josephs, Andrea ;Gauler, Rainer 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 327 KB

## Abstract Oxidative degradation studies of dimeric porphyrins provide valuable information about the individual linkages between the porphyrin units. MS and NMR data of the degradation products of hematoporphyrin derivative furnish unambiguous evidence of ester and ether linkages in the di‐ and o