𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Derivatives of Iressa, a Specific Epidermal Growth Factor Receptor Inhibitor, are Powerful Apoptosis Inducers in PC3 Prostatic Cancer Cells

✍ Scribed by Aurélie Telliez; Matthieu Desroses; Nicole Pommery; Olivier Briand; Amaury Farce; Guillaume Laconde; Amélie Lemoine; Patrick Depreux; Jean-Pierre Hénichart

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
813 KB
Volume
2
Category
Article
ISSN
1860-7179

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Cytotoxic effects induced by a combinati
Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells
✍ Murielle Mimeault; Erik Moore; Nicolas Moniaux; Jean-Pierre Hénichart; Patrick D 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 552 KB

## Abstract Although the blockade of the hedgehog cascade by using cyclopamine has been reported to inhibit the growth of some cancer cell types, few studies on the mechanism by which this drug alone or in combination with other cytotoxic agents induces its cytotoxic effect have been reported. In o

Inhibition of proliferation and inductio
Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 (‘Iressa’) is independent of EGFR expression level
✍ Manuela Campiglio; Alberta Locatelli; Clelia Olgiati; Nicola Normanno; Giulia So 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 297 KB 👁 2 views

High expression of the epidermal growth factor receptor (EGFR) in breast carcinoma confers a growth advantage to the tumor cells. The EGFR tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa') has clinical activity in a wide range of tumor types, although the mechanism(s) by which it exerts its ant

Early castration-induced upregulation of
Early castration-induced upregulation of transforming growth factor ?1 and its receptors is associated with tumor cell apoptosis and a major decline in serum prostate-specific antigen in prostate cancer patients
✍ Wikstr�m, Pernilla; Westin, Patrick; Stattin, P�r; Damber, Jan-Erik; Bergh, Ande 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 728 KB

## BACKGROUND. The mechanism behind castration-induced apoptosis in prostate cells is unknown, but data from other species suggest that transforming growth factor ␤1 (TGF-␤1) may be involved. METHODS. By using quantitative RT-PCR and immunohistochemistry, expression of TGF-␤1 and its receptors typ