Derivatives of 4,5,-dihydro-1,3,-dimethyl-1H-pyrazolo[3,4-b][1,4]benzoxazepine with antiinflammatory activity
โ Scribed by Swett, Leo R.; Stein, Robert G.; Kimura, Eugene T.
- Book ID
- 121461748
- Publisher
- American Chemical Society
- Year
- 1972
- Tongue
- English
- Weight
- 445 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
In a previous paper') we described the generation of o-lithiomethylphenyl isocyanide, which was a versatile reagent for syntheses of indole derivatives. Herein, we wish to report an elaboration of the lithiomethylphenyl isocyanide to lead to heterocycles such as 4,5-dihydro-3,1-benzoxazepine ~~ and
indolines were shown to undergo phosphorylation with phosphorus(III) halides at the two nucleophilic carbon centers to give fused 1,4-azaphosphinine ring systems. Chemical properties of the synthesized compounds were characterized. For some representative compounds, detailed NMR spectroscopic invest
In the title compound, C 11 H 14 N 2 O, the diazepine ring adopts a skewed boat conformation. The molecule is stabilized by N-Hร ร รO intermolecular hydrogen bonds, forming a zigzag chain parallel to the b axis.