✦ LIBER ✦

Derivatives of (2R)-N-Glyoxylbornane-10,2-sultam and Their Use as auxiliaries in the diastereoselective spirocyclization of 2-substituted tryptamines

✍ Scribed by Ralf Freund; Christos Allagiannis; Peter Schönholzer; Karl Bernauer

Publisher: John Wiley and Sons
Year: 1994
Tongue: German
Weight: 453 KB
Volume: 77
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19940770304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A crude hydrate 6 and a crystalline hemiacetal 7 of glyoxylamide 4 were prepared from crotonamide 5 (Scheme 2). Particularly hemiacetal 7, but also 6 and the ‘dimer’ 8 (obtained from 7) may serve as homochiral auxiliaries. The structure of 8 was determined by X‐ray analysis. By arenesulfonyl halides, tryptimines 12–14 of 4 were diastereoselectively transformed into spirotricycles 15–17 and 19.

📜 SIMILAR VOLUMES

ChemInform Abstract: Non-Destructive Rem

ChemInform Abstract: Non-Destructive Removal of the Bornanesultam Auxiliary in α- Substituted N-Acylbornane-10,2-sultams under Mild Conditions: An Efficient Synthesis of Enantiomerically Pure Ketones and Aldehydes.

✍ W. OPPOLZER; C. DARCEL; P. ROCHET; S. ROSSET; DE BRABANDER. J. DE BRABANDER. J. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views

ChemInform Abstract: Reaction of Hydrazi

ChemInform Abstract: Reaction of Hydrazines with N-Acetoacetyl Derivatives of (4S)-4-Benzyloxazolidin-2-one and (2R)-Bornane-10,2-sultam in Very Acidic Media to Give Pyrazoles Retaining the Chiral Moiety at C-3(5).

✍ Marcial Moreno-Manas; Rosa Maria Sebastian; Adelina Vallribera; Francesca Carini 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

The Reduction of Oxalic Amidines with Me

The Reduction of Oxalic Amidines with Metallic Lithium: Preparation of Lithiated Bisamides [R″N(RR′N)C=C(NRR′)NR″]Li2 and Their Use as Intermediates in a Novel Synthesis of Tetraaminoethenes

✍ Wenzel, Matthias ;Lindauer, Dirk ;Beckert, Rainer ;Boese, Roland ;Anders, Ernst 📂 Article 📅 1996 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 558 KB

Acute and Chronic Toxicity of Veratrum V

Acute and Chronic Toxicity of Veratrum Viride††The Veratrum viride studied was the whole-powdered drug marketed by Irwin, Neisler & Co. under the name, Vertavis. The work reported herein was supported by a grant from this firm. The batch of powder used in these experiments was stated by the manufacturer to have been assayed biologically by the Craw method on Daphnia magna. One Craw unit of the material studied was stated to be 15.6mg. With regard to this assay, Mr. R. O. Craw has been so kind as to allow us to publish a brief explanation: A reference lot of Yerolrum oirid; powder was set-aside as a standard and a 10% w/v aqueous extract was made of this powder. The average median length of life in 50 assays of 1000 daphnia on immersion in the solution was determined to be 2.22 hours. The daphnia were considered dead when the heart was found to be in systolic standstill on microscopic examination. Succeeding lots of powder were assayed and their potency determined by relating the median length of life of daphnia to 2.22 hours, which is one unit. Twenty assays of 10 animals each were used on each lot of powder.‡‡The authors wish to thank Dr. J. F. A.,McManus of the Department of Pathology for a pathologic report on the tissues, and Mr. James Thomas and Mrs. Bobby E. Teague for technical assistance.

✍ Perdue, Adoline S. ;Bell, Frances ;Starnes, W.R. ;Hitchcock, Philip ;Teague, R.S 📂 Article 📅 1950 🏛 Elsevier ⚖ 346 KB 👁 1 views