Stereoselective β-N-glycosylation of 2,3
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Tsutomu Yokomatsu; Tomoyuki Sada; Takanori Shimizu; Shiroshi Shibuya
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Article
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1998
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Elsevier Science
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French
⚖ 262 KB
N-glycolylation of 3-(diethoxyphosphorothioyl)methyl-5-O-benzoyl-l-O-ethyl-2,3-dideoxyriboses 9b ~d 10b with silylated thymine in the presence of TiCI4 proceeded highly diastereoselectively (92% de) to give the corresponding ~nucleotide analogues in good yield. A remarkable neighboring group partici