Derivate natürlicher Tetrapyrrole für die Photodynamische Therapie, 2 Modellreaktionen zur direkten CC-Verknüpfung von Porphyrinen
✍ Scribed by Risch, Nikolaus ;Mackenbrock, Ursula
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 434 KB
- Volume
- 1992
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Natural Tetrapyrrol Derivatives for the Photodynamic Therapy, 2. — Model Reactions for Direct C–C Linkages of Porphyrins
Until now, there is a lack of information about the structure of the active components in the diagnosis and photodynamic therapy of cancer with hematoporphyrin derivatives (HPD). We describe the formation of HPD in terms of benzyl cation chemistry. Selective formation of the C—C‐linked model compounds 4, 5 by reaction of protoporphyrin dimethyl ester (2) with electron‐rich aromatic compounds as well as of 9—12, 15–17, obtained by reaction of the porphyrin dimethyl esters 2, 6, 7, and 8, with carbon electrophiles (preformed Mannich salts), results from this concept.