Der Umbau von radioaktivem Phenylalanin und Tyrosin in Malaria-infiziertenCulex-Weibchen

✍ Scribed by Walter A. Maier; Hischam Nassif-Makki

• Publisher: Springer-Verlag
• Year: 1975
• Tongue: English
• Weight: 448 KB
• Volume: 46
• Category: Article
• ISSN: 1432-1955
• DOI: 10.1007/bf00383669

✦ Synopsis

Eingegangen am 5. September 1974

T h e M e t a b o l i s m of C14-Labeled P h e n y l a l a n i n e and T y r o s i n e in M a l a r i a -I n f e e t e d Culex F e m a l e s Summary. 1. Culex females are fed on C14-phenylManine or C14-tyrosine in sugar solution. Autoradiographie studies on homogenated femMes 1 or 4 days after feeding, show that the labeled amino acids are metabolized on the first day and are not detectable on the fourth day.

2. After increase of the amino acid concentration by saturation of the sugar solution with the unlabeled amino acid, the labeled acid and its metabolites are visible over a longer period of time.

3. PhenylManine is metabolized to tyrosine and at least four other substances. Radioactivity on the starting point of the chromatogram can be interpreted us incorporation of tyrosine into proteins.

4. After infection with Plasmodium cathemerium, and feeding of C14-phenyl-Manine C14-tyrosine is demonstrable over a longer period.