Der Einfluß von Bilirubin auf das Mechanogramm des isolierten, spontan schlagenden Froschherzens
✍ Scribed by U. Mittelstädt; J. Biester; K. Sandhage
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 408 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0340-6997
No coin nor oath required. For personal study only.
✦ Synopsis
It was shown that bilirubin in its unconjugated form does not only harm the central nervous system. Clinical observations indicate that the toxic effect under certain conditions affects also the heart. In a simple experimental model the influence of free bilirubin on the activity of the heart was investigated. In 69 adult frogs the heart was isolated and exposed sequentially to solutions of different bilirubin concentrations while the heart actions were registered. There was no significant change in the activity of the heart under the influence of bilirubin although concentrations were reached which according to the results of other authors harm cell cultures or evoke in the newborn disturbances in various organs. As a possible explanation, the nonsusceptibility of the heart muscle to bilirubin, the short duration of exposure, and the different behavior of newborn and adult organs is discussed.
📜 SIMILAR VOLUMES
Die vorliegende Meßkammer entstand in dem Bestreben, den Sauerstoffverbrauch des spontan schlagenden isolierten Froschherzens mit Hilfe einer polarographischen Methode fortlaufend zu registrieren bei gleichzeitiger Registrierung der Dynamik. Der ursprüngliche Versuch, den Sauerstoffdruek im Ventrike
rate bei den nicht gepaarten Weibchen des Stammes B unterschied sich nicht signifikant. Sie betrug fur die Versuchsgruppe o und fur die Kontrollgruppe 0,5%. Aus den Vcrsuchen geht hervor, daB zwar hormonelle Faktoren bei der Cancerogenese des virusbedingten Mamma-Carcinoms eine Rolle spielen, nicht