Der Einfluß adrenerger β-Blockade auf die Wärmebildung bei akuter Kälteexposition

✍ Scribed by C. -J. Estler; O. Strubelt; H. P. T. Ammon

• Publisher: Springer
• Year: 1966
• Tongue: English
• Weight: 647 KB
• Volume: 289
• Category: Article
• ISSN: 0031-6768
• DOI: 10.1007/bf00363809

✦ Synopsis

For the investigation of the influence of the fl-sympathicolytic agent propranolol on thermoregulation in white mice body temperature, oxygen consumption, glycogen, glucose, pyruvate and lactate in liver and skeletal muscle, and glucose, pyruvate, lactate and nnesterified fatty acids in the blood were determined. Control animals exposed to an environmental temperature of 0 ° C showed a fall of the body temperature by only 3,6 °, a rise of the oxygen consumption by 760/0, a decrease of the glycogen content of liver and muscle, and an increase of the unesterified fatty acids in the serum. After pretreatment with propranolol oxygen consumption was not increased and the body temperature fell by 17.1°. The glycogen content of liver and muscle was not significantly diminished and the level of unesterified fatty acids in the serum was not raised. These results lead to the suggestion that fi-sympathicolysis prevents the mobilization of carbohydrates and fat from the stores, which is necessary for the enhancement of metabolism and heat-production.