Der Abbau von Desoxyribonucleinsäure durch Ascorbinsäure: Die intermediäre Bildung von OH-Radikalen

✍ Scribed by K. Berneis

• Publisher: John Wiley and Sons
• Year: 1963
• Tongue: German
• Weight: 271 KB
• Volume: 46
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19630460108

✦ Synopsis

Abstract

Ascorbic acid in aqueous solution in the presence of molecular oxygen causes a degradation of deoxyribonucleic acid (DNA). This degradation can be completely suppressed by the addition of catalase or of peroxidase. It is concluded that the degradation of the DNA is due to the formation of hydrogen peroxide during the autoxidation of the ascorbic acid. Hydrogen peroxide itself is not very efficient in degrading DNA, but it is reduced by ascorbic acid to OH radicals which degrade the DNA.