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Deprotonation of hydrochloride salts of amino acid esters and peptide esters using commercial zinc dust

โœ Scribed by Ananda, K. ;Suresh Babu, V.V.


Book ID
110893719
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
60 KB
Volume
57
Category
Article
ISSN
1397-002X

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Coupling of Frnoc-amino acid chlorides mediated by activated commercial zinc dust for the synthesis of peptides is described. The reaction is carried out in an organic medium. The necessity of using an inorganic base like NaHCO3/Na2CO3 or an organic base like DIEA/NMM/TEA/pyridine is circumvented. T