Depression of thomsen-friedenreich (anti-T) antibody in humans with breast carcinoma
β Scribed by G. F. Springer; P. R. Desai
- Book ID
- 104835816
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 261 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0028-1042
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## BACKGROUND. It has been proposed that the Thomsen-Friedenreich glycotope represents a general carcinoma-associated antigen and a candidate for the development of a tumor vaccine. However, the expression of the unmasked and masked (sialylated) forms in lung carcinomas, as well as in developing a
Human polyclonal, monospecific anti-T and -Tn antibodies were found to be reactive in ELISA tests with human ovarian (IGROV-1, OVCAR-3 and SKOV-3), breast (SKBr-3 and T47D)- and oral (KB)-carcinoma cell lines, but less so or non-reactive with normal epithelia and fibroblasts. The direct binding radi