𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Depression of complement activity in three strains of mice after tumor transfer

✍ Scribed by Walter P. Drake; Stephen M. Legendre; Michael R. Mardiney Jr.

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
415 KB
Volume
11
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Both immune adherence and hemolytic complement activity were measured as a function of time after either intraperitoneal or subcutaneous injection of six transplantable tumors carried in three strains of mice. There was a lack of correlation between complement activity measured by these assays in accord with other studies on human cancer patients. The data indicate that host complement activity was depressed in all cases following tumor transfer and suggest that the serotherapy of murine tumors using passively administered anti‐tumor serum may be compromised by host complement insufficient to mediate tumor cytolysis in vivo.

πŸ“œ SIMILAR VOLUMES

The accelerating role of abelson murine
The accelerating role of abelson murine leukemia virus in murine plasmacytoma development: in vitro infection of spleen cells generates donor-type tumors after transfer to pristane-treated BALB/c mice
✍ Hiroyuki Sugiyama; GΓΌnther Weber; Santiago Silva; Magda Babonits; Francis Wiener πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 863 KB

The role of Abelson murine leukemia virus (A-MuLV) in the accelerated development of murine plasmacytomas (PCs) (Potter et a/., 1973: Science, 132, 592-594) was studied in a new experimental system. Spleen cells from pristane-treated or untreated BALBk mice carrying Robertsonian 6; I5 fusion chromos