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Depression in classic versus akinetic-rigid Parkinson's disease

✍ Scribed by Dr. Sergio E. Starkstein; Gustavo Petracca; Erán Chemerinski; Alejandra Tesón; Liliana Sabe; Marcelo Merello; Ramón Leiguarda

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
488 KB
Volume
13
Category
Article
ISSN
0885-3185

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✦ Synopsis

We examined the prevalence of major depression and dysthymia in 78 patients with the classic variant of Parkinson's disease (PD) (that is, tremor plus rigidity and/or bradykinesia), and in 34 patients with the akinetic-rigid variant. Although the prevalence of dysthymia was similar in both groups (classic PD, 31%; and akinetic-rigid PD, 32%), patients with akinetic-rigid PD had a significantly higher prevalence of major depression (38% versus 15%, respectively; p < 0.01). A stepwise regression analysis demonstrated that bradykinesia was the extrapyramidal sign with the highest correlation with Hamilton depression scale scores. Our findings demonstrate a significant association between major depression and the akinetic-rigid type of PD.

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