𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Depression comorbidity in spinocerebellar ataxia

✍ Scribed by Tanja Schmitz-Hübsch; Mathieu Coudert; Sophie Tezenas du Montcel; Paola Giunti; Robyn Labrum; Alexandra Dürr; Pascale Ribai; Perrine Charles; Christoph Linnemann; Ludger Schöls; Maryla Rakowicz; Rafal Rola; Elszbieta Zdzienicka; Roberto Fancellu; Caterina Mariotti; Lazlo Baliko; Bela Melegh; Alessandro Filla; Elena Salvatore; Bart P.C. van de Warrenburg; Sandra Szymanski; Jon Infante; Dagmar Timmann; Sylvia Boesch; Chantal Depondt; Jun-Suk Kang; Jörg B. Schulz; Thomas Klopstock; Nicole Lossnitzer; Bernd Löwe; Caroline Frick; Daniela Rottländer; Thomas E. Schlaepfer; Thomas Klockgether

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
123 KB
Volume
26
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society

📜 SIMILAR VOLUMES

Movement disorders in spinocerebellar at
Movement disorders in spinocerebellar ataxias
✍ Jose Luiz Pedroso; Andre C. Felicio; Pedro Braga-Neto; Orlando G.P. Barsottini 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 44 KB

We read the article by van Gaalen et al. 1 with great interest. These authors reviewed the frequency and main type of movement disorders found in each form of spinocerebellar ataxia (SCA). They also reported unusual movement disorders and noncerebellar manifestations, such as stiff-person syndrome,

Movement disorders in spinocerebellar at
Movement disorders in spinocerebellar ataxias
✍ Judith van Gaalen; Paola Giunti; Bart P. van de Warrenburg 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB

## Abstract Autosomal dominant spinocerebellar ataxias (SCAs) can present with a large variety of noncerebellar symptoms, including movement disorders. In fact, movement disorders are frequent in many of the various SCA subtypes, and they can be the presenting, dominant, or even isolated disease fe

Spectrin mutations in spinocerebellar at
Spectrin mutations in spinocerebellar ataxia (SCA)
✍ Peter Bauer; Ludger Schöls; Olaf Riess 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB

## Abstract Recently, βIII spectrins have been recognized as ataxia disease genes, with the identification by Ikeda and co‐workers of pathogenic mutations in the __SPTBN2__ gene in three large (and mapped) SCA5 families of American and European origin.^(1)^ With their discovery, the large “Lincoln”

Dystonia in spinocerebellar ataxia type
Dystonia in spinocerebellar ataxia type 6
✍ Kapil D. Sethi; Joseph Jankovic 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB

## Abstract Spinocerebellar ataxias are heterogeneous disorders with overlapping clinical features. Spinocerebellar ataxia‐6 is a dominantly inherited condition characterized by relatively pure ataxia with a paucity of other manifestations including extrapyramidal findings. We report on two patient

Trunk sway in patients with spinocerebel
Trunk sway in patients with spinocerebellar ataxia
✍ Bart P.C. Van de Warrenburg; Maaike Bakker; Berry P.H. Kremer; Bastiaan R. Bloem 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 268 KB

## Abstract We investigated whether quantified measurements of trunk sway during stance and gait tests in patients with autosomal dominant spinocerebellar ataxia (SCA) could be a useful approach to assess ataxia, which is highly relevant for adequate follow‐up and future intervention studies. Exami