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Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal

✍ Scribed by Hanson, Nicola D; Owens, Michael J; Nemeroff, Charles B


Book ID
120562689
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
559 KB
Volume
36
Category
Article
ISSN
1470-634X

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## Abstract The transcription factor CREB has been implicated in signalling pathways relevant for pathogenesis and therapy of depression. CREB is upregulated and activated in the hippocampus by chronic antidepressant treatment, similarly as neurogenesis. Surprisingly, a recent study using CREB‐defi