Depression and associated sleep disturbances: patient benefits with agomelatine
β Scribed by David J. Kupfer
- Book ID
- 118592433
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 126 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0924-977X
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## Abstract ## Background Disturbance of sleepβwake cycles is common in major depressive disorder (MDD), usually as insomnia, but also as hypersomnia or reduced daytime alertness. Agomelatine, an MT~1~ and MT~2~ receptor agonist and 5βHT~2C~ receptor antagonist, represents a novel approach in MDD,
Cognitive arousal has been associated with disrupted sleep in individuals with insomnia and may be one mechanism underlying sleep disturbances in depression. We evaluated the relationship of sleep to bereavement-related intrusive thoughts and avoidance behaviors in 40 men and women with major depres