๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Depressed natural killer cell activity in patients with hepatocellular carcinoma in vitro effects of interferon and levamisole

โœ Scribed by K. Son; M. Kew; A. R. Rabson

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
556 KB
Volume
50
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

Enriched lymphocytes from patients with primary hepatocellular carcinoma showed considerably reduced natural cytotoxicity against two established hepatoma cell lines and against the myelogenous derived cell line K562, as compared to lymphocytes from normal volunteers or from patients with various nonmalignant liver diseases. The serum of hepatoma patients did not effect normal or patient NK cell activity. When lymphocytes from patients or controls were treated for three hours with human leukocyte interferon, NK cell activity was significantly improved. Levamisole did not produce a significant increase in normal NK cytotoxicity but did improve the killing of lymphocytes from patients with hepatocellular carcinoma.

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