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Deposition of cocaine in tissue after lethal and repeated sublethal administration to sheep

✍ Scribed by Nowak, R. ;Balabanova, S. ;Brunner, H. ;Homoki, J. ;B�rger, B. ;Reinhardt, G.

Book ID
104662845
Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
300 KB
Volume
99
Category
Article
ISSN
1437-1596

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✦ Synopsis

The deposition of cocaine in tissue after lethal administration to sheep was investigated. In addition, the presence of cocaine in tissue obtained from sheep treated for 30 days with a sublethal dose (2.4 mg/kg b.wt.) after 1-day, 1-week, or 1-month withdrawal was studied. The determination of cocaine was performed by radioimmunoassay. The concentrations measured represent the sum of cocaine and its metabolites. The presence of cocaine was also qualitatively proven by gas chromatography/mass spectrometry. After a lethal dose administration cocaine was found in all investigated organs. The highest concentrations were present in liver, bile, and kidney. In tissue obtained from the sheep treated daily with a sublethal dose and killed after 1-week withdrawal, the concentrations found were significantly lower. After 1-month withdrawal, cocaine was not to be discovered in tissue.

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