✦ LIBER ✦

Depolymerization of chondroitin 6-sulfate and dermatan sulfate with diazomethane in the presence of a small proportion of water

✍ Scribed by Yuko Inoue; Kinzo Nagasawa

Publisher: Elsevier Science
Year: 1986
Tongue: English
Weight: 499 KB
Volume: 146
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(86)85046-7

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✦ Synopsis

Chondroitin 6-sulfate (sodium salt), dermatan sulfate (sodium salt), and their methyl esters were depolymerized into mixtures of methylated, even-numbered oligosaccharides having a 4,5-unsaturated uronic acid, nonreducing end-group, respectively, with excess diazomethane in the presence of a small proportion of water. The methyl ester of chondroitin 6-sulfate was more effectively cleaved than the sodium salt, whereas the methyl ester of dermatan sulfate was depolymerized at a rate slightly higher than the sodium salt. About half of the acetamido group in the depolymerized product of the methyl ester of these polysaccharides was N-methylated.

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