Depolarizing neuromuscular junctional blocking action of Parthenium hysterophorus leaf extracts in rat

✍ Scribed by Pineni Vijayalakshmi; Kattalath M. Vijayalakshmi; Nanguneri V. Nanda Kumar

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 195 KB
• Volume: 13
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199908/09)13:5<367::aid-ptr434>3.0.co;2-3

✦ Synopsis

Electromyographic (EMG) and electrodiagnostic studies were made on sciatic nerve-anterior tibialis muscle in vivo in rats administered with a sublethal dose of Parthenium hysterophorus dry leaf powder 100 mg/100 g body weight of rat. Nerve-evoked and muscle-evoked compound muscle action potentials were recorded at different frequencies of stimulations and at different time intervals. The EMG studies revealed depolarizing neuromuscular junctional (NMJ) blocking effects of the leaf extract. The decrement-increment (D-I) phenomena and the EMG pattern in general showed a resemblance to an established anticholinesterase agent like neostigmine. The studies confirm that the leaf extract contains a proven and promising new depolarizing NMJ blocker.