Depletion of taurine in the adult rat retina
β Scribed by Norma Lake
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 298 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0364-3190
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## Abstract Highβaffinity uptake, potassiumβstimulated release and receptor binding of Ξ³βaminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetateβmalate (IAM). Such treatments produce a selective damage of the inner retinal layers (
Guanidinoethane sulfonate (GES) markedly decreased 3H-taurine accumulated in the retina by the high-affinity uptake process. The effect of GES was dosedependent. Analysis of the kinetics of GES effect revealed that it is a competitive inhibitor. The uptake of taurine by GES was less affected in rat